Sildenafil is a medication that works by causing the smooth muscle cells lining the blood vessels to relax, improving blood flow to the penis. This medication takes approximately 30 minutes to start working, and the effects last between 4 and 6 hours. It’s the perfect way to spice up a date night or special occasion. When you’re taking Sildenafil, you can expect harder and longer-lasting erections when you become sexually aroused.

Tadalafil is a medication that works by relaxing the smooth muscle cells lining the blood vessels, leading to increased blood flow to the penis. Better blood flow means harder and longer-lasting erections for men taking Tadalafil. This medication takes approximately 30 minutes to take effect and works for an impressive 24 to 36 hours. With Tadalafil, there’s no pressure and no time constraints – just around-the-clock coverage for enhanced erections, adding spontaneity back to your sex life.

30 minutes to 1 hour before sexual activity. It can be taken with or without food, but if taken after a high-fat meal, it may take longer to work. Effects can last up to 24–36 hours.

Studies show combining PDE5 inhibitors like Sildenafil and Tadalafil may result in better erection quality, confidence, penetration, and satisfaction compared to single-agent therapy. This can enhance sexual performance, especially for men who haven’t achieved desired results with one medication alone.

Sildenafil and Tadalafil is designed for men 18 years and older who want to improve their sexual performance, especially those who may not have responded to a single medication or want enhanced effects.

Do not take Sildenafil (sildenafil citrate), Tadalafil, or Vardenafil if you take medication containing nitrates or guanylate cyclase stimulators for pulmonary hypertension as this could cause an unsafe drop in blood pressure. Discuss your health with your provider to ensure that you are healthy enough for sex. If you experience chest pain, dizziness, or nausea during sex, seek immediate medical help. Sildenafil, Tadalafil, and Vardenafil can cause serious side effects.

Some side effects include:

• An erection lasting more than 4 hours. If you experience a prolonged erection, seek immediate medical attention as this can cause permanent damage if left untreated.
• Sudden vision loss in one or both eyes. This can be a sign of a serious eye problem. Stop taking the medication and call your healthcare provider right away if you experience these symptoms.
• Sudden hearing decrease, hearing loss, ringing in the ears (tinnitus), or dizziness. If you experience these symptoms, stop taking the medication and contact a healthcare provider right away.

Before taking inform your healthcare provider if you:

• Have or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve, or heart failure
• Have had heart surgery within the last 12 months
• Have pulmonary hypertension
• Have had a stroke
• Have low blood pressure or high blood pressure that is not controlled
• Have a deformed penis shape
• Have had an erection that lasted for more than 4 hours
• Have problems with your blood cells such as sickle cell anemia, multiple myeloma, or leukemia
• Have retinitis pigmentosa, a rare genetic (runs in families) eye disease
• Have ever had severe vision loss, including an eye problem called NAION
• Have bleeding problems
• Have or have had stomach ulcers
• Have liver problems
• Have kidney problems or currently undergoing dialysis treatment
• Have any other medical conditions

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Sildenafil, Tadalafil, and Vardenafil may affect how other medicines work, and other medicines may affect how these medications work, causing side effects. Please inform your healthcare provider if you take any of the following:

• Nitrates- Guanylate cyclase stimulators such as Adempas (riociguat)
• Alpha-blockers such as Hytrin (terazosin HCl), Flomax (tamsulosin HCl), Cardura (doxazosin mesylate), Minipress (prazosin HCl), Uroxatral (alfuzosin HCl), Jalyn (dutasteride and tamsulosin HCl), or Rapaflo (silodosin).
• HIV protease inhibitors, such as ritonavir (Norvir), indinavir sulfate (Crixivan), saquinavir (Fortovase or Invirase), or atazanavir sulfate (Reyataz)
• Some types of oral antifungal medicines, such as ketoconazole (Nizoral) and itraconazole (Sporanox)
• Some types of antibiotics, such as clarithromycin (Biaxin), telithromycin (Ketek), or erythromycin
• Other medicines that treat high blood pressure
• Other medicines or treatments for ED

Sildenafil, Tadalafil, and Vardenafil should not be used with REVATIO or with other PAH treatments containing sildenafil, tadalafil, vardenafil, or any other PDE5 inhibitors (such as Adcirca tadalafil).

Sildenafil, Tadalafil, and Vardenafil do not protect against sexually transmitted diseases, including HIV.

The most common side effects of Sildenafil, Tadalafil, and Vardenafil include: headache, flushing, runny nose, congestion, throat or nose irritation, back pain, muscle pain, upset stomach, and heartburn.

INDICATION

Sildenafil, Tadalafil, and Vardenafil are active pharmaceutical ingredients found in prescription medications for erectile dysfunction (ED) and are also prescribed off-label for other conditions.